Many modern RF systems rely on the synchronized operation of multiple, simultaneous, wideband RF channels - from MIMO communications to spectral monitoring and electronic warfare systems. This presentation explains best practices for guaranteeing system synchronization and reliable triggering, achieving phase coherence, and creating real-time, multi-channel processing configurations. It also illustrates how to accelerate RF research by recording multi-channel RF data for post-processing. As a result of this presentation, attendees will better understand what steps they can take to configure and implement multi-channel, wideband RF systems for best performance.